About Altrazeal®

ULURU Inc. developed and commercializes Altrazeal®, a transforming powder dressing with proprietary Nanoflex® technology, for the management of exuding wounds.


What is Altrazeal®

Altrazeal® consists of a sterile white powder in a single-use, sterile foil laminate pouch or transparent blister.

Altrazeal® is applied to an exuding wound by slowly pouring the powder on the open wound. The particles then hydrate and agregate in the form in size of the wound bed. The agregated powder becomes a moist, flexible moisture permable film over the surface of the wound that provides an ideal moist wound environment supporting cellular function and tissue repair while preventing exogenous bacteria from penetrating the dressing. The dressing can remain and place up to 14 days as long as the wound produces exudate.

Altrazeal® is made from biocompatible polymers (contact lens material). Each gram of the lyophilized powder consists of: 84.8% poly-2-hydroxyethylmethacrylate (pHEMA), 14.9% poly- 2-hydroxypropylmethacrylate (pHPMA), and 0.3% sodium deoxycholate.

Altrazeal® is sterilised by irradiation.


Altrazeal® Benefits

  • Micro-contouring to the moist wound bed without bio-adhesion
  • Continuous total moisture content of 68% at the wound surface
  • High MVTR (12L per metre squared in 24 hrs) with low pressure at the wound – dressing interface stimulating healthy granulation tissue
  • Impermeable to bacteria
  • Decreased risk of peri-wound maceration
  • Flexibility with tensile strength
  • Improved patient comfort
  • Use for 7 days; can remain in place up to 14 days if exudate is present
  • Reduced dressing changes and nursing intervention
  • Secondary dressing may not be required

Mode of Action

Altrazeal® is made from a patented material designed to optimize the healing conditions of the wound bed environment. This engineered material is designed to provide specific properties to enhance wound healing.

Altrazeal mode of action 1

Altrazeal® is composed of polymer particles which upon contact with wound exudate aggregate irreversibly into a film dressing. This transformation occurs without any chemical reaction and the particles adhere and remain bound together as a dressing through hydrophobic/hydrophilic interactions, hydrogen bonding and Van der Waals forces.

The aggregation of the polymer particles creates a dressing with a high porosity that enables moisture transport away from the wound surface and the transport of oxygen to the wound surface, but whose pores are too small for exogenous bacteria to penetrate.

Altrazeal mode of action 2

A network of interconnected capillary channels allow the transport of fluid through capillary forces aided by moisture vapour evaporation at the surface (similar to the way a tree pulls moisture from the roots up to the leaves). High moisture vapour transpiration rate (“MVTR”) of 12,000g/m2/24 hours.

Altrazeal mode of action 3

The powder absorbs twice it‘s weight of water. Upon hydration, the matrix exhibits mechanical properties and water content similar to soft tissue. The matrix is a strong, resilient film covering which adheres to the wound surface.

When Altrazeal® aggregates to form the matrix a network of interconnected capillary channels is formed. This network of interconnected capillaries allows the transport of fluid through capillary forces aided by moisture vapour evaporation at the surface.

Altrazeal mode of action 4

The dressing provides intimate contact with the underlying wound and creates a moist wound environment supporting cellular function and tissue repair while preventing exogenous bacteria from penetrating the dressing.

Altrazeal mode of action 5

The fi lm matrix is strong but fl exible and elastic which prevents cracking or flaking under normal movement.

Altrazeal mode of action 6

As the wound heals, the Altrazeal® fl akes off at the edges.


Product Application Videos

Visit www.altrazeal.eu for clinical case studies, patient testimonials, application guidelines, and much more.