|
 |
|
|
|
|
Hydrogel Nanoparticle
Aggregate |
|
|
|
A Novel
Biomaterial |
|
|
|
|
|
|
|
1
|
2 |
3 |
4 |
5 |
6 |
7 |
|
|
|
|
|
|
|
Description: |
|
|
|
|
|
|
|
ULURU Inc. has
developed a novel, biomaterial which utilizes hydrogel
nanoparticles which aggregate to form a material of varying
strength and elasticity which has extensive application
including: |
|
|
|
|
|
|
|
- Wound
management and burn care
- Dermal
fillers
- Tissue
regeneration
-
Artificial
tissues
- Ocular
delivery
- Drug
delivery devices
|
|
|
|
Aggregates formed
of hydroxyl-terminated methacrylate monomers
(2-hydroxyethylmethacrylate and 2-hydroxypropylmethacrylate).
They are formed by injection of a suspension of purified
hydrogel nanoparticles that result in a permanent, porous
hydrogel implant. |
|
|
|
|
|
|
|
|
|
|
|
Hydrogel
nanoparticles aggregate through inherent physical forces with
a change in magnitude of Zeta potential or solutions ionic
strength. |
|
|
|
|
|
|
|
Nanoparticles
aggregates have a chemical composition identical to bulk
hydrogel polymers. |
|
|
|
|
|
|
|
Particles are
stabilized as a sol by a surfactant. |
|
|
|
|
|
|
|
The rate of pore
formation and cellular infiltration can be controlled to
optimize fibrous capsule formation. |
|
|
|
|
|
|
|
Aggregates have
minimal inflammatory response in long-term implant studies. |
|
|
|
|
|
|
|
Nanoparticle
aggregates are composed of a polymer that has been FDA
approved and used in implantable devices. |
|
|
|
|
|
|
|
1
|
2 |
3 |
4 |
5 |
6 |
7 |
|
|
|
|
|
