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Hydrogel Nanoparticle
Aggregate |
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Advantages: |
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Aggregates are
formed by injection of a suspension of hydrogel nanoparticles
which result in a porous, hydrogel implant. |
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Viscosity of
aggregate solution remains constant with changes in the
material properties. |
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Aggregate
composition can be tailored to fit a desired, specific
release profile e.g. macromolecule: |
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Release is
dependent on macromolecule, size and shape.
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Aggregate pore
sizes are set to deliver macromolecule at desired rate.
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Burst release can
be minimized.
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Incorporated
macromolecules are protected from enzymatic attack until
release. |
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The rate of pore
formation and cellular infiltration can be controlled to
optimize fibrous capsule formation. |
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Aggregates have
minimal inflammatory response as long-term implants. |
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Hydrogel
nanoparticles being composed of pHEMA, has excellent
biocompatibility properties. |
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Nanoparticle
aggregates are composed of a polymer that has been FDA
approved and used in implantable devices and contact lenses. |
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