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An additional
advantage of the ULURU hydrogel nanoparticle technology lies
in the ability to incorporate active compounds in implants,
and provide controlled release. Small and macromolecule drugs
are trapped within interstitial spaces between particles
during aggregate formation. The spaces between nanoparticles,
or holes in the lattice, can be tailored by varying the
nanoparticle size. These spaces have been used to encapsulate
proteins during aggregate formation. The ability to trap a
wide range of bioactive compounds between these particles in
the presence of water solutions offers another major
advantage, since this media is less deleterious to many
compounds than solvents typically used with other drug
delivery materials. |
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