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Formulation Flexibility:

Size of the nanoparticle and the physical properties of the resulting aggregate can be controlled during the synthesis

In Vivo physical properties of the aggregates can be varied to provide material that behaves like adipose tissue, collagen or articular cartilage.

Aggregates can be designed to provide a variety of porosites for optimum tissue growth if desired.

Aggregates have been optimized to perform with elastic shear and bulk material moduli that mimic biological tissue found at different levels of the dermal strata.

Molecules can be incorporated into the aggregates during formation for subsequent controlled release.

Physical properties such as strength and porosity of the aggregates can be varied by changing the nanoparticle size and with subtle changes in the composition ratio of monomers used in polymerization and crosslink density.

The rate of pore formation and cellular infiltration can be controlled to optimize tissue regeneration.

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