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dermal
technology
     
  Nanoflex® Technology Applications  
  Dermal Filler Technology  
 
  • Long-lasting sub-dermal filler
    • Can be used in conjunction with short residence dermal fillers composed of only hyaluronic acid.
    • Expands the market for commercial dermal fillers
    • Contains a higher ratio of nanoparticles to hyaluronic acid
  • Long-lasting dermal filler
    • Attributes of conventional dermal filler but with much longer residence time.
    • Contains a lower percentage of nanoparticles for higher collagen infiltration
  • Facial sculpting implant
    • Allows injectable implants for chin, cheekbone and maxillofacial sculpting.
    • Several formulations for different facial zones and specific applications.
    • Contains a lower percentage of hyaluronic acid and higher percentage of nanoparticles to provide less porous composition.
 
 
Nanoflex Dermal Fille Technology
  
  Dermal Filler Technology  
 
Electron Microscopy of Materials After Loss of Resorbable Material
 
     
 
 Histology of Tissue After Loss of Resorbable Material
  
     
  Partially Resorbable Dermal Filler  
  Aggregate injected in PBS and sonicated to speed dissolution of hyaluronic acid
  • Viscous gel composed of hyaluronic acid (HA), water and pHEMA nanoparticles
  • Composition can vary from 90% resorbable HA and 10% pHEMA to 10% HA and 90% pHEMA nanoparticles
  • Non-resorbable pHEMA maintains 85% of the original injection volume with aggregation
    • 10 % pHEMA composition results in a very porous scaffold
    • 90% pHEMA composition results in a denser, more compact scaffold

    ** IMAGE OF PARTIALLY RESORBABLE FILLER - slide 19**

  
     
  Aggregate Dermal Filler Attributes  
   

Aggregate Product Attributes
Conventional Product Attributes
Resorption over two or more years Resorption in 4-6 months

Two component resorption
 - Rapid resorbing hyaluronic acid
 - Long lasting nanoparticle component

Single component resorption
 - Composed of only crosslinked hyaluronic acid
Low viscosity allows fine needle injection Viscosity increases with increased crosslinking
Applicable to deeply scored facial features Limited applicability to deeply scored features
Applicable as facial sculpting material Does not apply to bone or hard tissue filling
 
     

Other applications Wound Care, Topical, Breast Implants and Ocular

 

 

© 2011 ULURU Inc.
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