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• Individual components of the Nanoparticle Aggregate Material were evaluated in a porcine model with no dermal irritation
  • Hydrogel material.
  • Stabilizing surfactant
  • Suspension medium
• TNF-α levels were evaluated in a porcine model
  • TNF-α levels with nanoparticle aggregate were not elevated over control.

• Study Design
  • Nanoparticle Suspensions were injected sub cutaneously in mice and allowed to form aggregates
  • Material was removed after 28 days
  • Lung, liver spleen and draining lymph nodes were excised and sectioned.
• Results
  • Nanoparticle aggregate mass was conserved and material did not migrate
  • Lung, liver, spleen and draining lymph nodes showed no particles in cells or tissue.

• No loss in aggregate mass over 28 days
• Limited capsule formation around aggregate

• Particles not found in liver, lung or spleen

• Study Design
  • Nanoparticle Aggregates were implanted sub cutaneously in mice
  • Material was removed after 90 days
  • Lung, liver spleen and draining lymph nodes were excised and sectioned.
• Results
  • Nanoparticle aggregate mass was conserved and material did not migrate
  • Lung, liver, spleen and draining lymph nodes showed no particles in cells or tissue.

• No loss of implanted aggregate mass