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• Synthetic, inert biocompatible biomaterial with extensive history in FDA-Approved devices.
  • Contact lenses, implants.
• Physical properties can be controlled by changing formulation variables,
  • Particle size
  • Crosslink density
  • Monomers and comonomers incorporated into formulation
• Physical characteristics
  • Material can be soft, duplicating collagen or adipose tissue characteristics
  • Material can be hard, approaching articular cartilage
• High water content promotes biocompatibility and cellular infiltration
• Potential to avoid common problems associated with permanent dermal fillers
  • Granuloma
  • Acute immune response